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138 In one study, sperm in semen samples were less susceptible to oxidative damage when exposed to a vitamin E-enriched environment

These changes correlate with increased GSH levels and decreased ACSL4 expression, thus mitigating ferroptotic cell death in IL-1stimulated chondrocytes and preserving cartilage integrity (187)

Indeed, it may not be entirely prudent to extrapolate animal studies to humans, but these data give credence to the fact that dietary supplements could modulate CYP enzymes in humans

Xu A, Deng F, Chen Y, Kong Y, Pan L, Liao Q, et al

reported a 40% decrease in IGF-1 protein levels during the early stages of tendon healing compared to intact tendons, with levels peaking at 4 weeks and remaining elevated through 8 weeks post-injury (Lyras et al., 2010)