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Principal component analysis and predictive modeling validate DEGs as indicators of DM1 ddPCR expression of the downregulated genes, especially those that localize mostly to the proximal tubule, strongly correlate with each other, while the two upregulated bladder-enriched genes, KRT20 and HPGD , correlate with one another (Fig

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doi: 10.1016/j.jcf.2015.03.003 62 ChuaFLaurentGJ

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Weight loss triggered by GLP-1 also decreases overall caloric expenditure and may lower thyroid hormone requirements, potentially leading to over-replacement if doses remain unchanged

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