The Children and Families Safe Act of 2003 defines child maltreatment as any recent act or failure to act on the part of a parent or caregiver which results in death, serious physical or emotional harm, sexual abuse or exploitation, or an act or failure to act which presents an imminent risk of serious harm [1]
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Nicotine exerts anti-inflammatory and immune-modulating effects through a mechanism dependent on the alpha7 nicotinic receptor31 and has been shown to suppress neuroinflammation and disease severity in experimental autoimmune encephalomyelitis.3235 The lower HR of unfavourable outcomes among past snuff users than among current snuff users in our main analysis may be explained by the proportion of participants who replaced smoking with snuff use after the first clinical symptoms of the disease
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