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Hollywood continues to probe the James Dean mystique, via telefilms starring Stephen McHattie (1976) and James Franco (2001), with a bigscreen look at the actor in the upcoming Life, starring Dane DeHaan

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Apart from these shared features, other genetic alterations, such as the loss of PTEN , NOTCH receptors and the CREB binding protein, are also observed and the importance of these defects has been functionally validated in vivo and in vitro [126]

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