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Serious safety concerns are rare but include: Systemic infections : Immunocompromised individuals, those with central venous catheters, or patients with damaged gut barriers face increased risk of bacteremia or fungemia from probiotic organisms [19] [20] Antibiotic resistance transfer : Some probiotic strains may carry antibiotic resistance genes Metabolic complications : Rare cases of D-lactic acidosis have been reported with high-dose probiotic use [25] Specific populations requiring caution include patients with severe acute pancreatitis (based on the PROPATRIA trial showing increased mortality), short bowel syndrome, immunosuppression (HIV/AIDS, chemotherapy, organ transplant recipients), and critically ill individuals

Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

For so long people who couldnt lose weight and keep it off have been told that their willpower simply wasnt strong enough, says Daniel Drucker, an endocrinologist at the University of Toronto, who researched GLP-1 alongside Mojsov in the 1990s

He acknowledged that other people may not qualify for the drugs indicated use and will seek alternatives

It functions better as a complement than a replacement