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This is in line with studies showing that GLP-1 increases vascular blood flow and activates glucose delivery into skeletal muscle via AMP-activated protein kinase (AMPK), thereby promoting muscle synthesis, reducing muscle breakdown ( The finding of higher values of the SMM/VAT ratio after therapy than at baseline, suggests that oral semaglutide could prevent a potential state of sarcopenic visceral obesity in T2D patients

10.1038/s41586-021-03663-4 75 VriezeA.Van NoodE.HollemanF.SalojrviJ.KootteR

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