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Recent advances in Nrf2 activators, such as synthetic triterpenoids and natural compounds, highlight the need for temporal precisionactivating Nrf2 early to preserve -cell function but avoiding chronic overexpression, which may promote cancer (Mohamadi et al., 2023)

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This approach is used for acute injuries, post-surgical recovery, or situations requiring aggressive tissue repair

coli MG1655 and its mutants were incubated with 10 mM GSH at 37 C for 2 h

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