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The key difference is that semaglutide users at the 2.4 mg dose report higher rates and longer duration of constipation compared to tirzepatide users, even at the highest 15 mg dose

Originally FDA-approved as Ozempic for type 2 diabetes in 2017, semaglutide was subsequently approved as Wegovy for chronic weight management in 2021 making it one of the most rigorously studied weight loss medications ever approved

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This suggests that switching can restart weight loss, at least in one direction

Many patients find that eating smaller meals, chewing slowly, and stopping when comfortably full helps reduce nausea and stomach discomfort