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Pulsatile Endocrine Signaling Models: The peptide combination supports experiments examining temporal dynamics of endocrine signaling

However, we did not observe any differences in the activity of the Nrf2 target genes NQO1 and TXNRD1 after 6 h of NAC, Zn, and Cu stimulation (Figure 1c,d), indicating that the Zn-induced increase in GSH 6 h after stimulation appears to be a direct effect independent of de novo synthesis of GCLC via Nrf2 activation

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Glutaminase regulation in cancer cells: a druggable chain of events

This approach enhances the robustness of the data and contributes to a more comprehensive pharmacodynamic profile