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doi: 10.1136/annrheumdis-2019-216303 106 MaWCheJChenWWangDZhangHZhaoY

In individuals homozygous for the C677T polymorphism in the MTHFR gene, low riboflavin status is associated with elevated plasma homocysteine, and in turn linked with a higher risk of cardiovascular disease and other chronic diseases (13, 14)

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Furthermore, interactions of brain interstitial A with microglia [87, 88] and exposure to transition metals [81,82,83] also contribute to oxidative stress in neurons

CrossRef Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system Mark A