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A 2006 double-blind crossover study published in Psychopharmacology found that transdermal nicotine significantly improved depressive symptoms in nonsmokers with major depressive disorder, suggesting that nicotinic receptor activation can enhance mood independently of smoking-related factors

C., Tsui, H., Boukhaled, G., Henriques da Costa, S., Frezza, C., Krawczyk, C

doi: 10.1089/jmf.2017.4080