Reactive oxygen species cause oxidation that exceeds the capacity of antioxidant defense system, leading to oxidative stress (26)
While the trial was not designed to formally disentangle weight lossmediated vs weightindependent mechanisms, the magnitude and durability of weight loss likely play a substantial role in risk modification. Clinicians should note that in SELECT, treatment discontinuation due to adverse events was 16% on semaglutide vs 8% on placebo, largely driven by GI events
The approval is based on the ADHERE study, where 69% of patients treated with Vyvgart Hytrulo regardless of prior treatment saw evidence of clinical improvement, including improvements in mobility, function and strength
Many patients will start out taking semaglutide, and then later switch to tirzepatide when the semaglutide is no longer effective
Support came from National Institutes of Health grants AI4782, AI120500, AI007051, DK082227 and GM008861