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The same fragment cocktails were also screened in the presence of TIN2 TBM , a short peptide previously shown to bind to TRF1 TRFH with a dissociation constant of 0.3 M, to allow for an initial assessment of binding site specificity (Fig

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10.1007/s00726-011-1206-6 Summary Keywords Pichia pastoris, peptide-crossing-blood-brain-barrier, delta-sleepinducing peptide, neurotransmitter balance, mouse model, PCPA-induced insomnia Citation Mu X, Qu L, Yin L, Wang L, Liu X and Liu D (2024) Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models