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In lean mice, neither hGH nor AOD9604 significantly altered the weight of epididymal white adipose tissue

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By histopathological and histomorphometry analyses, group D (treatment by 1% MVs + Eucerin) revealed a detectable increase in the epidermal layer and a decline in both inflammatory response and granulation tissue

GLP-1 directly regulates insulin secretion, while GLP-1 RAs have the potential to improve insulin sensitivity and glucose homeostasis by attenuating inflammatory pathways such as NF-B and the NLRP3 inflammasome signaling, thereby mitigating IR [40]

In contrast while male NTg mice didnt show significant deficits in STM, the CR-fed males performed better during the LTM test then DL-fed males (Fig