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To get to 2025 and beyond, we will: Continue to invest in science and apply scientific rigor to all we do Ensure PMI is an attractive and engaging employer for all creating an environment in which everyone is empowered to perform at their best Deliver innovation through our global footprint and scale Continue to improve our performance across key ESG areas most notably, addressing our product impact by moving away from cigarettes and enabling switching to better alternatives as quickly as possible Expand our portfolio away from tobacco and nicotine, leaning into our expertise in life and medical sciences and our ability to help consumers make better choices The magnitude of change needed is undeniable

Although the insulas role in interoceptive monitoring has been well characterized [80] and higher nAChR availability in the thalamus, PFC, and cerebellum has been positively correlated with increased pain sensitivity among abstinent smokers [96], relatively little neuroimaging work has focused on the neurobiological processes that may contribute to smoking- or withdrawal-related pain dysregulation