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The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4

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Its primary function is to transport long-chain fatty acids into the mitochondria , where they are converted into usable energy

This observation is particularly crucial when considering that many biologic medications, especially those administered via pre-filled pens, come in fixed doses that are not adjusted for patient weight