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Yes, both mazdutide and tirzepatide are approved for weight management in individuals with obesity or overweight with comorbidities, regardless of diabetes status

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One, tirzepatide sold under the brand name Mounjaro carries a warning specifically about birth control pills, stating that the medication could make them less effective

Critically, neither the original 2021 meta-analysis nor the 2025 JAHA study found a significant association between GLP-1 medications and pulmonary embolism

Mallal, S