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GLP-1 RAs promote weight loss [41], hence our findings of an increase in weight with GLP-1 RA therapy at 5 years was interesting

Like CaMKK2, the PKA signalling pathway is also considered to play a key role in the pathogenesis of bipolar disorder, as increased cyclic AMP levels and PKA activity have been frequently observed in post-mortem brains and peripheral cells of bipolar disorder patients [58,59,60,61]

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Bhashyam S, Fields AV, Patterson B, Testani JM, Chen L, Shen Y-t, Shannon RP: Glucagon-like peptide-1 increases myocardial glucose uptake via p38 MAP kinasemediated, nitric oxidedependent mechanisms in conscious dogs with dilated cardiomyopathy/clinical perspective