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Modern diagnosis of GERD: the Lyon Consensus

& Chauhan, V

Although these data do not entirely negate the argument that metformin mediates its anti-hyperglycemic actions via an inhibitory action on mitochondria complex 1, the evidence strongly suggests that further inhibition of function would worsen, and contribute to, the toxic effects of metformin, such as lactic acidosis, that are, albeit very rare (11)