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doi: 10.3389/fonc.2018.00367 23 Brahimi-HornCBerraEPouyssegurJ

212% of the population suffer from this benign disorder characterized by intermittent unconjugated hyperbilirubinemia

pyroglutamic (5-oxoproline) acidosis pyroglutamic (5-oxoproline) acidosis pathophysiology pathogenesis of pyroglutamic acidosis The primary driver may be cysteine deficiency : Cysteine deficiency causes glutamylcysteine to be shunted into 5-oxoproline

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These structures, while involved in disease progression, are not the root cause of neuronal degeneration and remain challenging to modulate without risking systemic side effects or impairing essential barrier functions