Bioorganic Chem
Importantly, the specificity of response to sera from patients with different CKD ( Figures 4J, K ), like focal segmental glomerulosclerosis (FGS), membranous nephropathy (MN), Alport syndrome (AS) and polycystic kidney disease (PKD) was tested, and the chip reacted similarly to human glomeruli in response to nephrotoxic serum and nephroprotective treatment, mirroring in vivo conditions
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L-Arginine Feature L-Arginine L-Carnitine Main Action Boosts nitric oxide, improves blood flow(by vasodilation) Supports energy and blood flow, helps NO indirectly Best For Mild ED, first natural step Poor response to ED meds, vascular/metabolic ED Typical Dose 2.56 g/day 2,000 mg/day (propionyl/acetyl) Adverse effects Generally safe Generally safe Citrulline supplements vs L-arginine Feature L-Arginine L-Citrulline Supplements How it works Direct NO precursor Converts to L-arginine, then NO Typical Dose 1,5006,000 mg/day 1,500 mg/day (studied) Side Effects GI discomfort, diarrhea (at high doses) Well-tolerated Best Use Mild-moderate ED Mild ED, or if L-arginine is ineffective L-Arginine vs
[DOI:10.1177/0748233711399324] [PMID] Choi YM, Kim HK, Shim W, Anwar MA, Kwon JW, Kwon HK, et al
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