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The enrollment period lasted from August 30, 2019, to March 20, 2020, and follow-up was completed on January 13, 2021.The participants were divided into four groups in a 1:1:1:1 ratio

The STEP 1 trial, published in the New England Journal of Medicine, found that participants using semaglutide 2.4mg lost an average of 14.9% of body weight over 68 weeks compared to 2.4% in the placebo group

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Kildegaard J, Buckley ST, Nielsen RH et al (2019) Elucidating the mechanism of absorption of fast-acting insulin aspart: the role of niacinamide