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Nicotine and its primary metabolite, cotinine, are well-known to interfere with the normal functioning of the endocrine system by triggering the release of catecholamines such as adrenaline

Dissociation of functional and anatomical brain abnormalities in unaffected siblings of schizophrenia patients

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In addition, evidence suggests that electronic nicotine delivery systems, including e-cigarettes, e-hookahs, and vape pens, are also dangerous, often in different ways than more traditional tobacco products

The legal framework is clear, no flavor bans are in force, and online ordering from EU-based retailers is straightforward for personal use