At the COP1 WD40b -DET1 interface, DET1 S312 forms a hydrogen bond with COP1 K689
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It is linked to other diseases such as metabolic syndrome, obesity, type 2 diabetes, cardiovascular disease, and hypertension
Women tend to notice this sooner and more acutely than men, partly because women typically start with longer hair that makes shedding more visible, and partly because the female demographic is disproportionately affected
Safety data indicate mostly mild gastrointestinal events (nausea, diarrhea, vomiting), dose-dependent, and often improved with titration