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While several CGRP knockout mice have been developed for studies of the physiological role, most of these studies focused on vasodilatory effects and some were confounded by simultaneously knocking out the calcitonin gene [90]

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5,6 The JAMA review concludes that though the WHI data stands to recommend against the use of HRT in older women for prevention of chronic diseases, treatment of women in early menopause for vasomotor symptoms is appropriate outside of specific contraindications