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Arch Pediatr Adolesc Med 2007

R., Dunaief, J

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further showed that in hippocampal I/R, BPC 157 regulated apoptotic gene networks by upregulating Egr1, Akt1, Kras, VEGFR2, NOS3, and NOS1, while simultaneously suppressing NOS2 and NF-B.63 Of particular relevance, increased Akt1/Kras activity suppresses BAX, whereas NF-B downregulation favors Bcl-2 expression, collectively counteracting apoptosis.89 Additional studies support these protective effects in other organs