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Qadri SM, Donkor DA, Nazy I, Branch DR, Sheffield WP

The CV benefits of the SGLT2 inhibitor on HF and CV death (primarily driven by HF) are observed with months and most likely are hemodynamically driven (simultaneous reduction in preload and afterload), while those of GLP-1s on MACE take 12 to 16 months to be seen and most likely are related to the drugs antiatherogenic effects

By activating these receptors, the medication may inadvertently alter the signaling of neurotransmitters involved in sleep

This gives your body a steady, sustained signal that mimics what would happen if you were producing GLP-1 at higher levels all the time

Understanding this pattern helps patients push through rather than abandoning treatment during the hardest stretch