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An upregulation of KYAT1 and AADAT may reflect a compensatory astrocytic response to diminished KYNA availability, whereby upregulation of KAT enzymes and glutamate uptake mechanisms attempts to restore NMDAR inhibition and stabilize glutamatergic tone

Food and Drug Administration issued safety communications linking the drugs, collectively called incretin mimetics, to serious complications such as pancreatic diseases

Those side effects include the risk of skin cancer but can also be neurological