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Three 20-week double-blind, placebo-controlled studies each with 34-week extensions were conducted to evaluate the efficacy and safety of sitagliptin in 410 pediatric patients aged 10 to 17 years with inadequately controlled type 2 diabetes, with or without insulin therapy (HbA1c 6.5-10% for patients not on insulin, HbA1c 7-10% for patients on insulin)
PLC- is the only PLC isoform without the PH domain and shows the closest homology with PLC-1 (Swann et al., 2006)
It did not increase the risk of nonfatal myocardial infarction, cardiovascular death, nonfatal stroke, or hospitalization for heart failure compared with placebo
Some have decades of research behind them
For each pathway we identified top 20 paths connecting them with most direct interactors
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