Sparks JA, Vanni KMM, Sparks MA, Xu C, Santacroce LM, Glynn RJ, Ridker PM, Solomon DH (2021) Effect of low-dose methotrexate on estimated glomerular filtration rate and kidney adverse events: a randomized clinical trial
The dosing schedule typically begins at 2.5 mg weekly for four weeks, with gradual increases in 2.5 mg increments after at least 4 weeks on the current dose, as tolerated
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Group 3 (DEX + SPAE 400): Received DEX (10 mg/kg, I/P) and SPAE orally at 400 mg/kg/day
Healthcare providers should review glucose data regularly and adjust treatment regimens accordingly