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Gallbladder Issues : Semaglutide may increase the risk of gallbladder-related problems, such as gallstones

Goldberg A, Graca S, Liu J, Rao V, Witchel SF, Pena A, et al

Older Adults Older individuals sometimes experience more fatigue on semaglutide because their metabolic flexibility (ability to adapt to different fuel sources) may be reduced compared to younger people

It is also essential to allow for a washout period , depending on your previous dose of semaglutide and your providers assessment

But for reproductive-age men who may want children, the standard first-line prescription of TRT deserves reconsideration in light of both the fertility risk it carries and the growing evidence that addressing the metabolic cause may be both safer and more effective