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Since then, similar results related to the reduced availability of opioid receptors in the supraspinal regions in CCI to the sciatic nerve [135] and the spared nerve injury model [136] have been reported

The frequency and duration of treatment are also important considerations

Still, larger studies are needed to confirm the safety of L-carnitine during pregnancy

Key challenges for clinical translation include the lack of consistent benefit, as large RCTs and systematic meta-analyses have failed to demonstrate efficacy of prebiotics/probiotics in ICU patients despite encouraging signals in individual studies (Lee et al., 2023)

Anaphylaxis was reported in a post-marketing clinical trial in one patient who had previous exposure to XIAFLEX for the treatment of Dupuytrens contracture