That pathway turns on genes that activate enzymes involved in producing glutathione
10.1001/jama.2015.9676 16 DaviesM
The results of Spearman correlation analysis of gut microbiota and plasma metabolites showed that the relative abundance of Firmicutes was positively correlated with the level of 2-hydroxycinnamic acid, a well-known antioxidant (73, 74), suggesting that Firmicutes could exert antioxidant function by increasing the level of 2-Hydroxycinnamic acid
This creates a dangerous cycle: toxin buildup increases oxidative stress, which further depletes glutathione, making detoxification even less efficient
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