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Fluoroacetamides 4a and 4b were non-reactive across the kinases we investigated, independently of the electron-withdrawing substitution

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The distinct mode of CTR and AMYR engagement by Cagri revealed in the current study, together with the correlated distinctions in functional responses at individual receptors, is likely to be important in the differentiated, high efficacy, of Cagri as a first-in-class obesity drug in both preclinical animal models and in treatment of obese patients in clinical trials 2,3,4

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2018 Dec;18:3-14