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Risk increases with higher doses (especially above 1800mg daily), concurrent opioid use, older age, and pre-existing GI conditions like irritable bowel syndrome

Lower blood volume forces the heart to contract harder to maintain blood pressure, and that increased contractility can manifest as palpitations

The key is to plan ahead

Levels of glutathione may decline over time and can be influenced by factors such as age, lifestyle, diet, and environmental exposure , leading to increased interest in supplemental forms