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Another possible contributor to the observed cigarette smoking-induced epidermal hyperkeratinization is nicotine which has also been shown to increase various differentiation markers including filaggrin, involucrin, TG1 in keratinocytes 19 mediated by the activation of nicotinic acetylcholine receptors abundant in the skin 28

The cigarette holder will color over time as it is smoked, just as the meerschaum pipes color

HIFs are dimeric transcription factors with an oxygen-labile -subunit and a constitutively expressed -subunit located in the nucleus [11, 12]

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