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For patients at moderate risk of rhabdomyolysis who are at low risk of fluid overload, consider empiric IV fluid administration (e.g., D5LR at 150 ml/hr)

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(March 2014)

In the rat model, bidirectional effects on nitric oxide synthases have been observed: stimulation of the endothelial form (eNOS) with simultaneous inhibition of the inducible form (iNOS), suggesting a role in maintaining vascular homeostasis