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As an important guard against experimenter effects biasing results, participants, investigators, and outcome assessors were all not told participants experimental condition (i.e., they were kept blind to study condition)

In OA chondrocytes, chronic exposure to mechanical overload and inflammatory stimuli such as interleukin-1 and tumor necrosis factor- disrupts cellular redox homeostasis, rendering the glutamateGSH antioxidant system susceptible to oxidative damage

doi: 10.1016/j.jad.2020.01.065, 60

Schmued, L

Researchers continuously administered melanotan II to male MIA mice for seven days and observed a rescue of social behavioral metrics.'' The authors concluded that MT-II was an effective agent for improving autism-like behavioral deficits in the MIA mouse model of autism, suggesting that further research in this area is warranted [8]