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If this trend improvement is sustained over future periods, it implies significant positive impacts on population health and economic impacts extending beyond healthcare costs to reductions in absenteeism and disability and improved productivity

67,68 The GSH-antibiotic conjugate is more water-soluble and can be expelled, reducing the effective drug concentration

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These medications work on two hormone pathways instead of just one, which might make them even more effective

This is a result of the phosphorylation of myosin light chain that occurs in the peri junctional actomyosin ring to encourage TJ disassembly (Cunningham and Turner 2012