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Editor information Editors and Affiliations Rights and permissions Copyright information 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Namin, A., Brown, R.F

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While Melanotan II activates all five melanocortin receptor subtypes, PT-141 was designed to preferentially target MC3R and MC4Rthe receptors most involved in sexual responsewhile minimizing activation of MC1R (responsible for tanning) and MC5R

Cells stained as described above without permeabilization served as negative controls of intracellular staining, as previously reported (37)