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PFIC are inherited in an autosomal recessive manner, indicating that patients carry mutations in both alleles of the disease gene

Clin Pharmacol Ther 34(1):4853 [DOI] [PubMed] [Google Scholar] Monig H, Baese C, Heidemann HT, Ohnhaus EE, Schulte HM (1990) Effect of oral contraceptive steroids on the pharmacokinetics of phenprocoumon

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After first reconstitution (puncturing the rubber stopper with a sterile needle to introduce bacteriostatic water), the vial's internal environment is exposed, though the rubber stopper reseals when the needle is removed

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