can chewing tobacco cause stomach problems CDC - Fact Sheet - Smokeless Tobacco: Health Effects Effects of Smokeless Tobacco Use

By contrast, phasic activity is related to event-locked increase in firing 22 , which can typically be observed as a synchronous increase in firing rate in a population of neurons, but is not necessarily composed of bursts of action potentials (i.e., it can be single spikes but time-locked to an event during successive trials)

And its not just surface buildup of chemicals that are a concern

Hua M, Yip H, Talbot P

Only a short while earlier, we saw a single page where three paragraphs of neatly-written, neatly-worded text about the psychological effects of nicotine withdrawal flank a picture of a man having his brains yanked out by hooks

[17] The second line was commonly some variation on No filter, no flavor, it tastes like toilet paper , [18] or, No filter, no taste, just a fifty-cent waste