GIR is a measure of the ability of insulin to enhance glucose internalization and removal of glucose production, that is, a measure of tissue sensitivity to insulin in each animal
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The second step comprises an irreversible oxidative decarboxylation reaction catalyzed by the branched-chain -keto acid dehydrogenase complex (BCKDH), which represents the rate-limiting step of the entire metabolic pathway and directs metabolism toward complete oxidation (19)