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For example, intradiscal injection of bone morphogenetic protein-2 (BMP-2) induced degenerative changes [92] and weekly intradiscal treatment with growth and differentiation factor-5 (GDF-5) or insulin-like growth factor-1 (IGF-1) resulted in inflammatory reactions in the adjacent vertebrae and connective tissue infiltrates in the NP, causing the IVD to collapse [93]

Low Back Pain ReliefDo you suffer from low back pain

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This can cause pain, numbness, or tingling in your lower back, buttocks, and legs

For injections into the knee joint, there are four basic portals of entry: superolateral, superomedial, anterolateral, and anteromedial