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169 Chronic hyperglycemia decreases the complexity and differentiation of 3xTg-AD newborn neurons and depressed synaptic facilitation, accompanied by defective hippocampal-dependent memory, 109 suggesting that diabetes promotes changes in AD neurogenesis that ultimately exacerbates cognitive impairment

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Postmortem studies in brains of patients with these diseases have found that mitochondrial dysfunction is a common event leading to the degeneration and death of neuronal cells (Schon and Manfredi, 2003

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2009, 532640-7 pages, 2009