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Common pathophysiological features exist between T2DM, AD, and PD, including oxidative stress, inflammation, insulin resistance, abnormal protein processing, and cognitive decline, and suggest that effective drugs for T2DM that positively impact the gutbrain axis could provide an effective treatment option for neurodegenerative diseases

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These include selenium, alpha-lipoic acid, NAC, and SAMe

A significant effect on diastolic function was instead noted on a study using liraglutide [154] that demonstrated at a CMR analysis using a 4D flow dataset with retrospective valve tracking, improved early (E) and late (A) trans-mitral peak flow rate, E/A ratio values, along with improved early deceleration peak, early peak mitral annular septal tissue velocity (Ea) and estimated LV filling pressure (E/Ea)

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