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Yes, semaglutide is generally safe after gallbladder removal, but you may experience more frequent or severe GI side effects like diarrhea and bloating due to altered bile acid handling

It belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists, which were originally developed for treating type 2 diabetes but have demonstrated significant efficacy in promoting weight loss

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A caveat of using these medications is that many have reduced renal clearance due to declining kidney function or are contraindicated and often require careful dose adjustments [11,12,13]