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No controlled human trial was identified

146 This protective mechanism is exerted by the prevention of BH 4 oxidation by the increased superoxide

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Specifically, the ROS scavenger butylated hydroxyanisole delayed TNF-induced necroptosis but had no effect on necroptosis induced by direct RIPK3 oligomerization, suggesting that ROS may facilitate upstream signaling events rather than serve as an obligate execution mechanism 80

Whatever the mechanism, oxygen consumption by lees appears to be the main factor involved in white wines aged on lees being able to age for longer than other white wines