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Gastrointestinal absorption of Vitamin B12 depends on the presence of sufficient intrinsic factor and calcium ions

The core types include typical chronic cholestatic diseases, especially primary biliary cholangitis, primary sclerosing cholangitis, and acute-on-chronic liver failure [4, 181]

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Studies have found that a low concentration of calcium and a high concentration of magnesium (a low Ca:Mg ratio) in the intestines activate magnesium absorption