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The VPA-exposed group exhibited intense Iba1 immunostaining, indicating pronounced proinflammatory microglial activation compared to controls (P 0.05)

Therefore, basic research to clinical transformation remains the rate-limiting step in the development of treatment strategies for ASD, and the degree of heterogeneity may be considered, which may obscure the effect of experimental treatments

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Glutathione is not a "quick fix" for lifestyle challenges

It was reported that BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels (Patel et al., 2016), and CRY1 and 2 deficient mice had reduced IGF-1 production ( Due to the difficulty in measuring pulsatile GH secretion, the interaction between the GH-IGF-1 axis and circadian clock warrants further detailed research